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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Synergism of MSC-secreted HGF and VEGF in stabilising endothelial barrier function upon lipopolysaccharide stimulation via the Rac1 pathway

Fig. 8

RhoA and Rac1 activities in LPS-stimulated HPMECs were restrained by the RhoA and Rac1 inhibitors, respectively. The results showed that C3 transferase significantly inhibited RhoA activity (Fig. 8a and b) and that NSC23766 inhibited Rac1 activity (Fig. 8a and c) in injured HPMECs treated with MSCs or VEGF/HGF. n = 3, *p < 0.05; **p < 0.01 vs. MSC group; # p < 0.05 vs. LPS group; &p < 0.05; &&p < 0.01 vs. VEGF/HGF group. CM Conditioned medium, HGF Hepatocyte growth factor, LPS Lipopolysaccharide, MSC Mesenchymal stem cell, VEGF Vascular endothelial growth factor

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