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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Synergism of MSC-secreted HGF and VEGF in stabilising endothelial barrier function upon lipopolysaccharide stimulation via the Rac1 pathway

Fig. 9

MSC-secreted VEGF and HGF reduced LPS-stimulated HPMEC permeability by upregulating Rac1 activity in HPMECs. Our research showed that the effect of MSCs on reducing endothelial a paracellular and b transcellular permeability was weakened when injuried HPMECs were pretreated with the Rac1 inhibitor NSC23766. Similarly, the roles of VEGF and HGF in improving endothelial permeability were significantly inhibited by NSC23766 pretreatment. n = 3, *p < 0.05, *p < 0.01 vs. MSC group; # p < 0.05 vs. LPS group and vs. VEGF/HGF group. CM Conditioned medium, EC Endothelial cell, HGF Hepatocyte growth factor, LPS Lipopolysaccharide, MSC Mesenchymal stem cell, VEGF Vascular endothelial growth factor

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Stem Cell Research & Therapy

ISSN: 1757-6512