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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Modeling autosomal dominant optic atrophy using induced pluripotent stem cells and identifying potential therapeutic targets

Fig. 6

Neuron induction medium (NIM) promoted OPA1 +/−-RGC generation detected by IF. Neurospheres derived from the control and VO-iPSCs in the presence of NIM were plated onto PLO/L-coated plates and were cultured with hESC medium containing 10 μM DAPT, 10 % FBS, and 10 % NIM for 14 days. Cells were fixed with 4 % PFA on day 31. a TUJ1 (green) and BRN3a (red) staining are shown. b TUJ1 (green) and ISLET1 (red) staining are shown. Scale bars = 20 μM

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Stem Cell Research & Therapy

ISSN: 1757-6512