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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: PSA-NCAM positive neural progenitors stably expressing BDNF promote functional recovery in a mouse model of spinal cord injury

Fig. 8

Anterograde tracing of the CST. Overview of confocal micrographs of sagittal sections showing the area of the spinal cord between the CST end and 2 mm caudal to the lesion center (LC) of a transplanted BDNF-GFP NPCs, b transplanted GFP NPCs, and c vehicle-treated animals. Pictures below the main panels show details by higher magnification z-stack micrographs of representative areas at 0.5, 1 and 2 mm distance from the LC. White squares in the overview images show higher magnification panels of the respective end of the CST. d Quantification of BDA-positive CST fibers. The quantity of CST fibers at 0.5 mm distance was significantly elevated in animals transplanted with BDNF-GFP as compared with animals transplanted with GFP NPCs (p = 0.035) or compared with vehicle-treated animals (p = 0.035). The average of n = 4 mice (four adjacent sections per mouse) ± SEM is presented with *p <0.05, one-way ANOVA comparing three groups for each distance with consecutive post-hoc Tukey’s test. BDA biotinylated dextran amine, BDNF brain-derived neurotrophic factor, GFP green fluorescent protein

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