Table 1 Surface profile of HSCs in mouse and human [7]
From: Hematopoietic stem cell transplantation for multiple sclerosis: is it a clinical reality?
CD marker | Synonym | Main expression | Function |
|---|---|---|---|
CD3 | T3, leu4 | T cell | Mediated T-cell signal transduction and used in Lin cocktail |
CD4 | T4, leu3 | MHC-II, T cell, macrophage/monocytes, dendritic cells | Initiate early phase of T-cell activation and used in Lin cocktail |
CD8 | T8 | MHC-I, T-cell subsets | T-cell-mediated killing, and used in Lin cocktail |
CD11b | CR3, MAC 1 | Macrophage/monocytes, dendritic cells, granulocytes, NK cells | Phagocytosis, adhesion interaction of macrophage/monocytes, granulocytes, and used in Lin cocktail |
CD11c | CR4 | Macrophage/monocytes, granulocytes, NK cells | Similar to CD11b, cell–cell interaction during inflammatory response, and used in Lin cocktail |
CD34 | Gp105/120, Mucosialin | Precursor of hematopoietic cells, endothelial cells | Cell adhesion |
CD38 | T10 | Lymphoid cells, macrophage/monocytes | Cell adhesion and transduction |
CD45R | B220, Ly-5 | T cells and mostly B cells | T-cell and B-cell antigen receptor-mediated signaling, and used in Lin cocktail |
CD59 | MIRL | T cells, NK cells, granulocytes, erythroid, macrophage/monocytes | Complement cascade regulation |
CD117 | c-Kit | HSCs/progenitor cells and mast cells | Survival of mast cells, activation, proliferation, and chemotaxis |
CD161 | NK1.1 | NK cells | NK cell-mediated cytotoxicity, proliferation, and used in Lin cocktail |
SCA-1 | Ly6A/E | HSCs, HPCs, some lymphoid and myeloid cells | Mice HSCs are positive |
Gr1 | Ly-6G | Monocytes and granulocytes | Used in Lin cocktail |
Ter119 | Ly76 | Erythroid cells | Used in Lin cocktail |