Fig. 3
From: The cell cycle as a brake for β-cell regeneration from embryonic stem cells
Proposed differentiation models. a Embryonic stem (ES) cells can differentiate into functional β cells within 3–4 months in small numbers. b Modulating the cell cycle machinery of ES cells by transient overexpression of the CDK4–cyclin D2 complex prior to β-cell differentiation protocols may seem to be an attractive direction for the large-scale generation of functionally mature β cells in less time