Fig. 6
From: The effects of immunomodulation by macrophage subsets on osteogenesis in vitro
Transient M1 macrophage-driven inflammation is a crucial step for osteogenesis by osteoprogenitors (OPs). Delayed (72 hours) phenotypical modulation of M1 macrophages into mM2 macrophages by IL-4 therapy improves osteogenesis by OPs. mM2 M2 macrophages modulated from M1 phenotype