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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells

Fig. 2

Transgene expression in chondrogenically-induced hMSCs upon administration of rAAV vectors. hMSC aggregates were transduced with the various vectors or vector combinations as described in Fig. 1 and in Methods. Samples were histologically processed after 21 days to detect the expression of TGF-β and SOX9 by immunohistochemistry (magnification × 4; all representative data) a and to monitor the production of TGF-β by ELISA b as described in Methods. **Statistically significant compared with group 1 (rAAV-lacZ) (**P ≤0.010). TGF-β transforming growth factor beta

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Stem Cell Research & Therapy

ISSN: 1757-6512