Fig. 5
From: Attenuation of teratoma formation by p27 overexpression in induced pluripotent stem cells
Effect of miPSCs-p27 on functional recovery of ischemic heart in vivo. a, b Histologic assessment of LV cross section after Masson’s trichrome staining which stained visible scar region as blue. Infarction size was significantly reduced in miPSC and miPSC-p27 injection groups as compared with the DMEM injected group showing extensive scar formation. *P < 0.05. c–e Functional recovery of LV was significantly improved by miPSC and miPSC-p27 transplantation, whereas DMEM transplantation groups showed loss of function as analyzed by (c) LV end-diastolic volume (LVDEV), d LV end-systolic volume (LVESV), and (e) LV ejection fraction (LVEF) using echocardiography. *P < 0.05. miPSC mouse induced pluripotent stem cell, miPSCs-p27 p27 overexpressing mouse induced pluripotent stem cells