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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Genome-wide gene expression analyses reveal unique cellular characteristics related to the amenability of HPC/HSCs into high-quality induced pluripotent stem cells

Fig. 2

Genome-wide signature analyses reveal the unique characteristics related to HPC/HSC reprogramming. a Morphology differences during the reprogramming process of HPC/HSCs and MEFs. Scale bar, 100 μm. b Principle component analysis of global gene expression patterns in HPC/HSCs, MEFs, R1 ESCs, and iPSCs. The analysis of each cell line was based on two biological replicates. c Gene ontology (GO) of highly expressed genes in HPCs/HSCs. d GO of highly expressed genes in MEFs. c, d X axis depicts the P value. e Gene expression analyses of mesenchymal genes, epithelial genes, and cell cycle-related genes in HPC/HSCs and MEFs. The cluster analysis is presented as the mean ± SD based on two biological replicates. f Comparison of expression analyses of indicated genes in HPC/HSCs and MEFs (n = 3 measurements). Error bars indicate the SD. g Western blot comparing the levels of the indicated genes in HPC/HSCs and in MEFs. D day, HPC/HSC hematopoietic progenitor and stem cell, iPSC induced pluripotent stem cell, MEF mouse embryonic fibroblast

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