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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Intravitreal administration of multipotent mesenchymal stromal cells triggers a cytoprotective microenvironment in the retina of diabetic mice

Fig. 5

Most donor mesenchymal stromal cells (MSCs) do not differentiate into neural- or perivascular-like cells. On days 1, 4, 8 and 12 weeks after MSC administration, immunofluorescences were performed in eye sections to evaluate differentiation of MSCs into RGCs by a colocalization of green fluorescent protein (GFP) with the RGC marker β3-tubulin or b differentiation into retinal astrocytes by colocalization of GFP with the astrocyte marker GFAP. c To evaluate differentiation of MSCs into perivascular cells, immunofluorescences were performed to colocalize GFP with the pericyte marker NG2 in whole mount retinal preparations. Lectin was also added to detect blood vessels. Qualitative data are representative of six eyes per analyzed time

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