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Table 1 Summary of the key findings on the therapeutic effects of MSCs

From: Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy

Therapeutic effect on MSCs Method/finding Source of MSCs Wound-healing model Reference
Increased delivery Three-dimensional collagen allograft Rat bone marrow Rat [29]
  Microsphere-based engineered skin loaded with EGF Mouse bone marrow Mouse [31]
Increased migration CXCL12/CXCR4 axis Mouse bone marrow Mouse [32]
  Platelet-rich plasma Human amniotic fluid Human [34]
  EMPB Mouse Mouse [35]
Increased survival Biomimetic pullulan-based hydrogel Mouse Mouse [36]
Increased immunomodulation Polarization of macrophages to M2 phenotype Human gingival tissue Mouse [37]
  Increased miRNA-146a Mouse bone marrow Mouse [16]
  MSC-derived TSG-6 Human bone marrow Mouse [42]
Increased angiogenesis Biomimetic hydrogel scaffold Mouse bone marrow Mouse [43]
  LLLT Dog adipose tissue Mouse [44]
  14S,21R-diHDHA Mouse Mouse [45]
  v-myc introduction Human adipose tissue Mouse [47]
Increased wound-healing efficacy Hypoxia Human amniotic fluid Mouse [49]
  Hypoxia Human adipose tissue Mouse [50]
  Hypoxia Human bone marrow Mouse [51]
  1. 14S,21R-diHDHA 14S,21R-dihydroxydocosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid, EGF epidermal growth factor, EMPB Mallotus philippinensis bark, LLLT low-level laser therapy, miRNA microRNA, MSC mesenchymal stem cell, TSG-6 tumor necrosis factor-alpha-stimulated protein 6