Mesenchymal stem cells and cutaneous wound healing: novel methods to increase cell delivery and therapeutic efficacy

Table 1 Summary of the key findings on the therapeutic effects of MSCs

Therapeutic effect on MSCs	Method/finding	Source of MSCs	Wound-healing model	Reference
Increased delivery	Three-dimensional collagen allograft	Rat bone marrow	Rat	[29]
	Microsphere-based engineered skin loaded with EGF	Mouse bone marrow	Mouse	[31]
Increased migration	CXCL12/CXCR4 axis	Mouse bone marrow	Mouse	[32]
	Platelet-rich plasma	Human amniotic fluid	Human	[34]
	EMPB	Mouse	Mouse	[35]
Increased survival	Biomimetic pullulan-based hydrogel	Mouse	Mouse	[36]
Increased immunomodulation	Polarization of macrophages to M2 phenotype	Human gingival tissue	Mouse	[37]
	Increased miRNA-146a	Mouse bone marrow	Mouse	[16]
	MSC-derived TSG-6	Human bone marrow	Mouse	[42]
Increased angiogenesis	Biomimetic hydrogel scaffold	Mouse bone marrow	Mouse	[43]
	LLLT	Dog adipose tissue	Mouse	[44]
	14S,21R-diHDHA	Mouse	Mouse	[45]
	v-myc introduction	Human adipose tissue	Mouse	[47]
Increased wound-healing efficacy	Hypoxia	Human amniotic fluid	Mouse	[49]
	Hypoxia	Human adipose tissue	Mouse	[50]
	Hypoxia	Human bone marrow	Mouse	[51]

14S,21R-diHDHA 14S,21R-dihydroxydocosa-4Z,7Z,10Z,12E,16Z,19Z-hexaenoic acid, EGF epidermal growth factor, EMPB Mallotus philippinensis bark, LLLT low-level laser therapy, miRNA microRNA, MSC mesenchymal stem cell, TSG-6 tumor necrosis factor-alpha-stimulated protein 6

ISSN: 1757-6512