Fig. 9
Decidua-derived mesenchymal stem cell (DMSC) treatment after experimental autoimmune encephalomyelitis (EAE) triggering. a EAE mice were subjected to DMSC administration every 3–4 days, beginning at day 6 (D6) or at day 10 (D10) after MOG35–55 injection (arrows). Daily mean clinical scores from one representative out of two independent experiments are shown. b Statistical significance by unpaired t-test for mean scores at different days after immunization. c Area under the curve (AUC) was calculated between days 0 and 33 post-immunization (p.i.) (D0–33), and differences between groups were analyzed using the Mann–Whitney test; standard error of the means are shown; n = 16 mice/group. d Disease incidence at day 20 p.i. was analyzed by Fisher’s test. The bar graphs for representation of the disease incidence contingency table show the numbers of symptomatic and asymptomatic mice at day 20 p.i. for each group. *p < 0.05, **p < 0.01, ***p < 0.001