Fig. 3From: Retinoic acid receptor signaling preserves tendon stem cell characteristics and prevents spontaneous differentiation in vitroRAR agonists can prevent tenogenic differentiation and other instructed mesenchymal lineages in rat ATSCs (passage 6) following long-term differentiation in confluent conditions a–i. Stimulation with osteogenic d, g, adipogenic e, h, and chondrogenic f, i media caused a time-dependent increase in alkaline phosphatase d, g, LipidTOX-Green/Foxo1 e, h and Aggrecan/Col2a1 f, i respectively. Addition of tazarotene to the induction media causes a decrease in all differentiation markers a–i. Values are given as the mean ± SD, n = 3. *p <0.05, **p <0.005, ***p <0.001. DMSO dimethyl sulfoxideBack to article page