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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Retinoic acid receptor signaling preserves tendon stem cell characteristics and prevents spontaneous differentiation in vitro

Fig. 3

RAR agonists can prevent tenogenic differentiation and other instructed mesenchymal lineages in rat ATSCs (passage 6) following long-term differentiation in confluent conditions a–i. Stimulation with osteogenic d, g, adipogenic e, h, and chondrogenic f, i media caused a time-dependent increase in alkaline phosphatase d, g, LipidTOX-Green/Foxo1 e, h and Aggrecan/Col2a1 f, i respectively. Addition of tazarotene to the induction media causes a decrease in all differentiation markers a–i. Values are given as the mean ± SD, n = 3. *p <0.05, **p <0.005, ***p <0.001. DMSO dimethyl sulfoxide

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Stem Cell Research & Therapy

ISSN: 1757-6512