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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Retinoic acid receptor signaling preserves tendon stem cell characteristics and prevents spontaneous differentiation in vitro

Fig. 6

Differentiation potential of tazarotene-expanded TSCs is conserved upon withdrawal. Tazarotene-expanded cells from passage 9 were cultured with or without the compound for three further passages and induced to differentiate towards different mesenchymal lineages a. Both conditions were equally able to differentiate into osteocytes, adipocytes, and chondrocytes as seen by upregulation of alkaline phosphatase, LipidTOX, and aggrecan staining b, c, e, f, h, i. However, TSCs at the same passage cultured in a constant presence of tazarotene did not differentiate d, g, j. DMSO dimethyl sulfoxide, Taz tazarotene

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Stem Cell Research & Therapy

ISSN: 1757-6512