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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Retinoic acid receptor signaling preserves tendon stem cell characteristics and prevents spontaneous differentiation in vitro

Fig. 7

Tazarotene induces Scx nuclear localization through histone modifications. Human TSCs from passage 4 were co-treated for 4 DIV with histone methyltransferase and acetyltransferase inhibitors in the presence of tazarotene a–c. Addition of BIX-01294, a histone methyltransferase inhibitor, was able to suppress Scx nuclear localization induced by tazarotene, while C646, a histone acetyltransferase inhibitor, did not have any effect b, c. DMSO dimethyl sulfoxide, Scx scleraxis

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Stem Cell Research & Therapy

ISSN: 1757-6512