Table 2 Enriched biological processes based on downregulated proteins

 Tricarboxylic acid cycle

CS, FH, SUCLA2, MDH2, IDH3G, SUCLG2

SUCLG1, ACO2, PDHB, IDH3A

0.0000

 Succinyl-CoA metabolic process

SUCLA2, SUCLG2, SUCLG1

0.0004

 mitochondrial electron transport, NADH to ubiquinone

NDUFA9, NDUFB9, NDUFA8, NDUFB8, NDUFS8, NDUFB10

NDUFS5, NDUFA10, NDUFB3, NDUFS3, DLD, NDUFV1

0.0000

 Mitochondrial electron transport, ubiquinol to cytochrome c

UQCRC1, UQCR10

0.0335

 2-Oxoglutarate metabolic process

IDH3G, DLD, IDH3A

0.0253

 Malate metabolic process

FH, MDH2, ME2

0.0042

 Isocitrate metabolic process

IDH3G, IDH3A

0.0335

 Branched chain family amino acid metabolic process

HIBADH, HIBCH, BCAT2

0.0298

 Proline biosynthetic process

PYCR1, PYCR2

0.0479

 NADH metabolic process

MDH2, IDH3G, IDH3A

0.0060

 Aspartate transport

SLC25A12, SLC25A13

0.0479

 Malate-aspartate shuttle

SLC25A12, SLC25A13

0.0137

 Regulation of acetyl-CoA biosynthetic process from pyruvate

PDP1, PDHB, DLD

0.0128

 Oxaloacetate metabolic process

CS, MDH2, PCK2

0.0106

 Protein targeting to mitochondrion

TOMM40, TOMM34, TIMM44, TOMM22

0.0198

 Nuclear mRNA splicing, via spliceosome

SF3B4, PRPF4, SF3A2, SNRPD1, DHX38

GEMIN5, USP39, WDR77, LSM2

0.0001

 Translational elongation

GFM1, RPL21, RPL22, RPL13, RPL27, EEF2, TUFM

0.0099

 DNA-dependent DNA replication initiation

MCM7, MCM3, MCM6

0.0253

 tRNA modification

QTRT1, SSB, NSUN2

0.0335

 Ribonucleoprotein complex assembly

SF3A2, SNRPD1, CIRBP, GEMIN5, USP39, WDR77

0.0147

 Detection of oxygen

SOD2, ENG

0.0335

 DNA damage response, detection of DNA damage

MRPS9, PARP1, MRPS35

0.0017