Fig. 2

Effect of 5-FU on bone marrow cellularity. Hematoxylin and eosin-stained sections of decalcified femur (a) and affected histology on D2, D4, and D10 (b–d) after 5-FU treatment. Gradual decrease in bone marrow cells is observed on D2 (b) and D4 (c) with lowest cellularity on D4 (c) compared with control (a). By D10, endogenous recovery of hematopoiesis is seen (d). Note an influx of RBCs on D2 and D4. Scale bar = 20 μm. All images are taken on the Nikon 90i microscope. D2-5-FU, D4-5-FU, D10-5-FU days post 5-fluorouracil treatment