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Table 1 List of genes up-regulated by LL-37

From: LL-37 stimulates the functions of adipose-derived stromal/stem cells via early growth response 1 and the MAPK pathway

Gene name

Accession No

Fold increase

Classification

Early growth response 1 (EGR1)

NM_001964

18.47

Transcription, Immune response

Early growth response 2 (EGR2)

NM_000399

6.13

Transcription

High mobility group AT-hook 2 (HMGA2)

NM_003483

4.72

Transcription

Response gene to complement 32 (RGC32)

NM_014059

4.33

Cell cycle

Solute carrier family 20 (phosphate transporter) (SLC20A1)

NM_005415

4.19

Signal transduction

Dual specificity phosphatase 1 (DUSP1)

NM_004417

3.94

Cell cycle

Dual specificity phosphatase 6 (DUSP6)

NM_001946

3.74

Cell cycle, Signal transduction

Connective tissue growth factor (CTGF)

NM_001901

3.71

Cell migration, Cell growth, Cell adhesion, Signal transduction

Kruppel-like factor 10 (KLF10)

NM_005655

3.31

Transcription, Signal transduction, Cell proliferation

Dachsous 1 (Drosophila) (DCHS1)

NM_003737

3.05

Cell adhesion

Tumor necrosis factor receptor superfamily, member 12A (TNFRSF12A)

NM_016639

2.98

Apoptosis, Cell adhesion

Pleckstrin homology-like domain, family A, member 2 (PHLDA2)

NM_003311

2.94

Apoptosis

v-fos FBJ murine osteosarcoma viral oncogene homolog (FOS)

NM_005252

2.80

Transcription, Inflammatory response, Immune response

Tribbles homolog 2 (Drosophila) (TRIB2)

NM_021643

2.56

Cell adhesion

Tubulin, beta 2C (TUBB2C)

NM_006088

2.52

Transport, Apoptosis

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (RAPH1)

NM_213589

2.46

Signal transduction

Myeloid cell leukemia sequence 1 (BCL2-related) (MCL1)

NM_021960

2.34

Apoptosis

SH2B adaptor protein 3 (SH2B3)

NM_005475

2.26

Cell cycle, Signal transduction

Cysteine-rich, angiogenic inducer, 61 (CYR61)

NM_001554

2.19

Cell adhesion, Cell proliferation

Sphingosine kinase 1 (SPHK1)

NM_021972

2.10

Cell migration, Apoptosis, Cell cycle, Cell proliferation

Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 (RAPH1)

NM_213589

2.01

Signal transduction

  1. The fold increase indicates the increase in expression in comparison to control cells, as determined by a human cDNA microarray