Fig. 4

Lin28A over-expression alters several glycolytic enzymes. Densitometry analysis of Western blot data (a) showed that hexokinase II (c) and PDH (f) expression was significantly increased in Lin28A over-expressers. However, PKM2 (e) and LDHA (g) were significantly decreased in Lin28A over expressers. No change was observed in Hex I (b) or PFKP (d). (Student’s unpaired t-tests were used to compare between experimental groups. Data are represented as mean ± SEM, n = 4. PDH pyruvate dehydrogenase, PKM2 pyruvate kinase muscle isoform 2, LDHA Lactate dehydrogenase A, Hex I hexokinase I, PFKP pyruvate fructose kinase phosphate