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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Relevance of HCN2-expressing human mesenchymal stem cells for the generation of biological pacemakers

Fig. 4

Proliferation and cell cycle of transfected and non-transfected hMSCs. a Proliferation rate of non-transfected (negative control), pIRES-EGFP-transfected (pIRES control) and pIRES-mHCN2-EGFP-transfected (mHCN2-transfected) hMSCs over 72 h. Control, pIRES-, and mHCN2-transfected cells were investigated after their growth with geneticin for 5 days. Changes in proliferation rate were significant (p < 0.05) compared to the non-transfected cells. b Representative profiles of cell population (left) and DNA content (right) of mHCN2-transfected hMSCs. c Summarized quantitative percentage of each cell cycle phase. Data are presented as means ± SD. *Data were significant compared to the negative control at p < 0.05. Proliferation of transfected cells was measured 5 days after their growth with geneticin (50 μM). Non-transfected cells grew for 72 h and were analyzed in parallel. Data are presented as means ± SD

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