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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Liver-derived human mesenchymal stem cells: a novel therapeutic source for liver diseases

Fig. 2

Signaling pathways of LHMSC differentiation into hepatocytes in vitro. Hepatic differentiation can be divided into three stages: induction, differentiation and maturation. Sequential addition of cytokines to the medium plays a vital role at each stage. DEX dexamethasone, EBP enhancer binding protein, EGF epidermal growth factor, EGFR epidermal growth factor receptor, ERK1/2 extracellular-signal-regulated kinase 1/2, FGF fibroblast growth factor, HGF hepatocyte growth factor, HNF4 hepatocyte nuclear factor 4, ITS insulin-transferrin-selenium, MAPK mitogen-activated protein kinase, OSM oncostatin M, PI3K phosphoinositide 3-kinase, NTA nicotinamide

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