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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Properties of internalization factors contributing to the uptake of extracellular DNA into tumor-initiating stem cells of mouse Krebs-2 cell line

Fig. 4

Internalization of supercoiled pUC19 plasmid DNA by Krebs-2 cells in the presence of various competitors. The relative internalization efficiency of pUC19 plasmid DNA in the presence of different amounts of human dsDNA (a), yeast RNA (b), bovine serum albumin (BSA) (c), and heparin (d). The values are shown on a log pUC19 (pUC19 + competitor) scale. e FACS analysis of Alu-TAMRA dsDNA internalization by human mesenchymal stem cells (MSCs) in the presence or absence of heparin. The data obtained suggest that heparin is a dose-dependent inhibitor of plasmid DNA internalization and suppresses linear DNA internalization by the cells. *p < 0.05; **p < 0.01; # p < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512