TY - JOUR AU - Vierbuchen, T. AU - Ostermeier, A. AU - Pang, Z. P. AU - Kokubu, Y. AU - Sudhof, T. C. AU - Wernig, M. PY - 2010 DA - 2010// TI - Direct conversion of fibroblasts to functional neurons by defined factors JO - Nature VL - 463 UR - https://doi.org/10.1038/nature08797 DO - 10.1038/nature08797 ID - Vierbuchen2010 ER - TY - JOUR AU - Nam, Y. J. AU - Song, K. AU - Luo, X. AU - Daniel, E. AU - Lambeth, K. AU - West, K. PY - 2013 DA - 2013// TI - Reprogramming of human fibroblasts toward a cardiac fate JO - Proc Natl Acad Sci U S A VL - 110 UR - https://doi.org/10.1073/pnas.1301019110 DO - 10.1073/pnas.1301019110 ID - Nam2013 ER - TY - JOUR AU - Szabo, E. AU - Rampalli, S. AU - Risueno, R. M. AU - Schnerch, A. AU - Mitchell, R. AU - Fiebig-Comyn, A. PY - 2010 DA - 2010// TI - Direct conversion of human fibroblasts to multilineage blood progenitors JO - Nature VL - 468 UR - https://doi.org/10.1038/nature09591 DO - 10.1038/nature09591 ID - Szabo2010 ER - TY - JOUR AU - Du, Y. AU - Wang, J. AU - Jia, J. AU - Song, N. AU - Xiang, C. AU - Xu, J. PY - 2014 DA - 2014// TI - Human hepatocytes with drug metabolic function induced from fibroblasts by lineage reprogramming JO - Cell Stem Cell VL - 14 UR - https://doi.org/10.1016/j.stem.2014.01.008 DO - 10.1016/j.stem.2014.01.008 ID - Du2014 ER - TY - JOUR AU - Huang, P. AU - He, Z. AU - Ji, S. AU - Sun, H. AU - Xiang, D. AU - Liu, C. PY - 2011 DA - 2011// TI - Induction of functional hepatocyte-like cells from mouse fibroblasts by defined factors JO - Nature VL - 475 UR - https://doi.org/10.1038/nature10116 DO - 10.1038/nature10116 ID - Huang2011 ER - TY - JOUR AU - Huang, P. AU - Zhang, L. AU - Gao, Y. AU - He, Z. AU - Yao, D. AU - Wu, Z. PY - 2014 DA - 2014// TI - Direct reprogramming of human fibroblasts to functional and expandable hepatocytes JO - Cell Stem Cell VL - 14 UR - https://doi.org/10.1016/j.stem.2014.01.003 DO - 10.1016/j.stem.2014.01.003 ID - Huang2014 ER - TY - JOUR AU - Sekiya, A. AU - Suzuki, A. PY - 2011 DA - 2011// TI - Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors JO - Nature VL - 475 UR - https://doi.org/10.1038/nature10263 DO - 10.1038/nature10263 ID - Sekiya2011 ER - TY - JOUR AU - Lee, J. S. AU - Ward, W. O. AU - Liu, J. AU - Ren, H. AU - Vallanat, B. AU - Delker, D. PY - 2011 DA - 2011// TI - Hepatic xenobiotic metabolizing enzyme and transporter gene expression through the life stages of the mouse JO - PLoS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0024381 DO - 10.1371/journal.pone.0024381 ID - Lee2011 ER - TY - JOUR AU - Yu, B. AU - He, Z. Y. AU - You, P. AU - Han, Q. W. AU - Xiang, D. AU - Chen, F. PY - 2013 DA - 2013// TI - Reprogramming fibroblasts into bipotential hepatic stem cells by defined factors JO - Cell Stem Cell VL - 13 UR - https://doi.org/10.1016/j.stem.2013.06.017 DO - 10.1016/j.stem.2013.06.017 ID - Yu2013 ER - TY - JOUR AU - Zhao, R. AU - Duncan, S. A. PY - 2005 DA - 2005// TI - Embryonic development of the liver JO - Hepatology VL - 41 UR - https://doi.org/10.1002/hep.20691 DO - 10.1002/hep.20691 ID - Zhao2005 ER - TY - JOUR AU - Bort, R. AU - Signore, M. AU - Tremblay, K. AU - Martinez Barbera, J. P. AU - Zaret, K. S. PY - 2006 DA - 2006// TI - Hex homeobox gene controls the transition of the endoderm to a pseudostratified, cell emergent epithelium for liver bud development JO - Dev Biol VL - 290 UR - https://doi.org/10.1016/j.ydbio.2005.11.006 DO - 10.1016/j.ydbio.2005.11.006 ID - Bort2006 ER - TY - JOUR AU - Zhao, R. AU - Watt, A. J. AU - Li, J. AU - Luebke-Wheeler, J. AU - EE, E. E. AU - Duncan, S. A. PY - 2005 DA - 2005// TI - GATA6 is essential for embryonic development of the liver but dispensable for early heart formation JO - Mol Cell Biol VL - 25 UR - https://doi.org/10.1128/MCB.25.7.2622-2631.2005 DO - 10.1128/MCB.25.7.2622-2631.2005 ID - Zhao2005 ER - TY - JOUR AU - Clotman, F. AU - Lannoy, V. J. AU - Reber, M. AU - Cereghini, S. AU - Cassiman, D. AU - Jacquemin, P. PY - 2002 DA - 2002// TI - The one-cut transcription factor HNF6 is required for normal development of the biliary tract JO - Development VL - 129 ID - Clotman2002 ER - TY - JOUR AU - Qiu, Q. AU - Hernandez, J. C. AU - Dean, A. M. AU - Rao, P. H. AU - Darlington, G. J. PY - 2011 DA - 2011// TI - CD24-positive cells from normal adult mouse liver are hepatocyte progenitor cells JO - Stem Cells Dev VL - 20 UR - https://doi.org/10.1089/scd.2010.0352 DO - 10.1089/scd.2010.0352 ID - Qiu2011 ER - TY - JOUR AU - Shin, S. AU - Walton, G. AU - Aoki, R. AU - Brondell, K. AU - Schug, J. AU - Fox, A. PY - 2011 DA - 2011// TI - Foxl1-Cre-marked adult hepatic progenitors have clonogenic and bilineage differentiation potential JO - Genes Dev VL - 25 UR - https://doi.org/10.1101/gad.2027811 DO - 10.1101/gad.2027811 ID - Shin2011 ER - TY - JOUR AU - Pear, W. S. AU - Miller, J. P. AU - Xu, L. AU - Pui, J. C. AU - Soffer, B. AU - Quackenbush, R. C. PY - 1998 DA - 1998// TI - Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow JO - Blood VL - 92 ID - Pear1998 ER - TY - JOUR AU - Morgenstern, J. P. AU - Land, H. PY - 1990 DA - 1990// TI - Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line JO - Nucleic Acids Res VL - 18 UR - https://doi.org/10.1093/nar/18.12.3587 DO - 10.1093/nar/18.12.3587 ID - Morgenstern1990 ER - TY - JOUR AU - Takahashi, K. AU - Yamanaka, S. PY - 2006 DA - 2006// TI - Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors JO - Cell VL - 126 UR - https://doi.org/10.1016/j.cell.2006.07.024 DO - 10.1016/j.cell.2006.07.024 ID - Takahashi2006 ER - TY - JOUR AU - Serrano, F. AU - Calatayud, C. F. AU - Blazquez, M. AU - Torres, J. AU - Castell, J. V. AU - Bort, R. PY - 2013 DA - 2013// TI - Gata4 blocks somatic cell reprogramming by directly repressing Nanog JO - Stem Cells VL - 31 UR - https://doi.org/10.1002/stem.1272 DO - 10.1002/stem.1272 ID - Serrano2013 ER - TY - JOUR AU - Donato, M. T. AU - Ponsoda, X. AU - O’Connor, E. AU - Castell, J. V. AU - Gomez-Lechon, M. J. PY - 2001 DA - 2001// TI - Role of endogenous nitric oxide in liver-specific functions and survival of cultured rat hepatocytes JO - Xenobiotica VL - 31 UR - https://doi.org/10.1080/00498250110052111 DO - 10.1080/00498250110052111 ID - Donato2001 ER - TY - JOUR AU - Ma, L. AU - Chung, W. K. PY - 2015 DA - 2015// TI - Quantitative analysis of copy number variants based on real-time LightCycler PCR JO - Curr Protoc Hum Genet VL - 80 ID - Ma2015 ER - TY - JOUR AU - Chen, C. AU - Ridzon, D. A. AU - Broomer, A. J. AU - Zhou, Z. AU - Lee, D. H. AU - Nguyen, J. T. PY - 2005 DA - 2005// TI - Real-time quantification of microRNAs by stem-loop RT-PCR JO - Nucleic Acids Res VL - 33 UR - https://doi.org/10.1093/nar/gni178 DO - 10.1093/nar/gni178 ID - Chen2005 ER - TY - JOUR AU - Lahoz, A. AU - Donato, M. T. AU - Picazo, L. AU - Castell, J. V. AU - Gomez-Lechon, M. J. PY - 2008 DA - 2008// TI - Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry JO - Drug Metab Lett VL - 2 UR - https://doi.org/10.2174/187231208785425845 DO - 10.2174/187231208785425845 ID - Lahoz2008 ER - TY - JOUR AU - Donato, M. T. AU - Montero, S. AU - Castell, J. V. AU - Gomez-Lechon, M. J. AU - Lahoz, A. PY - 2010 DA - 2010// TI - Validated assay for studying activity profiles of human liver UGTs after drug exposure: inhibition and induction studies JO - Anal Bioanal Chem VL - 396 UR - https://doi.org/10.1007/s00216-009-3441-1 DO - 10.1007/s00216-009-3441-1 ID - Donato2010 ER - TY - JOUR AU - Zaret, K. S. PY - 2008 DA - 2008// TI - Genetic programming of liver and pancreas progenitors: lessons for stem-cell differentiation JO - Nat Rev Genet VL - 9 UR - https://doi.org/10.1038/nrg2318 DO - 10.1038/nrg2318 ID - Zaret2008 ER - TY - JOUR AU - Hanna, J. AU - Saha, K. AU - Pando, B. AU - Zon, J. AU - Lengner, C. J. AU - Creyghton, M. P. PY - 2009 DA - 2009// TI - Direct cell reprogramming is a stochastic process amenable to acceleration JO - Nature VL - 462 UR - https://doi.org/10.1038/nature08592 DO - 10.1038/nature08592 ID - Hanna2009 ER - TY - JOUR AU - Watt, A. J. AU - Garrison, W. D. AU - Duncan, S. A. PY - 2003 DA - 2003// TI - HNF4: a central regulator of hepatocyte differentiation and function JO - Hepatology VL - 37 UR - https://doi.org/10.1053/jhep.2003.50273 DO - 10.1053/jhep.2003.50273 ID - Watt2003 ER - TY - JOUR AU - Chang, J. AU - Nicolas, E. AU - Marks, D. AU - Sander, C. AU - Lerro, A. AU - Buendia, M. A. PY - 2004 DA - 2004// TI - miR-122, a mammalian liver-specific microRNA, is processed from hcr mRNA and may downregulate the high affinity cationic amino acid transporter CAT-1 JO - RNA Biol VL - 1 UR - https://doi.org/10.4161/rna.1.2.1066 DO - 10.4161/rna.1.2.1066 ID - Chang2004 ER - TY - JOUR AU - Cooke, A. R. AU - Harrison, D. D. AU - Skyring, A. P. PY - 1963 DA - 1963// TI - Use of indocyanine green as a test of liver function JO - Am J Dig Dis VL - 8 UR - https://doi.org/10.1007/BF02232323 DO - 10.1007/BF02232323 ID - Cooke1963 ER - TY - JOUR AU - Huch, M. AU - Dorrell, C. AU - Boj, S. F. AU - Es, J. H. AU - Li, V. S. AU - Wetering, M. PY - 2013 DA - 2013// TI - In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration JO - Nature VL - 494 UR - https://doi.org/10.1038/nature11826 DO - 10.1038/nature11826 ID - Huch2013 ER - TY - JOUR AU - Dorrell, C. AU - Erker, L. AU - Schug, J. AU - Kopp, J. L. AU - Canaday, P. S. AU - Fox, A. J. PY - 2011 DA - 2011// TI - Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice JO - Genes Dev VL - 25 UR - https://doi.org/10.1101/gad.2029411 DO - 10.1101/gad.2029411 ID - Dorrell2011 ER - TY - JOUR AU - Yamanouchi, K. AU - Zhou, H. AU - Roy-Chowdhury, N. AU - Macaluso, F. AU - Liu, L. AU - Yamamoto, T. PY - 2009 DA - 2009// TI - Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation JO - Hepatology VL - 49 UR - https://doi.org/10.1002/hep.22573 DO - 10.1002/hep.22573 ID - Yamanouchi2009 ER - TY - JOUR AU - Joseph, B. AU - Berishvili, E. AU - Benten, D. AU - Kumaran, V. AU - Liponava, E. AU - Bhargava, K. PY - 2004 DA - 2004// TI - Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions JO - Nat Med VL - 10 UR - https://doi.org/10.1038/nm1057 DO - 10.1038/nm1057 ID - Joseph2004 ER - TY - JOUR AU - Bar-Nur, O. AU - Verheul, C. AU - Sommer, A. G. AU - Brumbaugh, J. AU - Schwarz, B. A. AU - Lipchina, I. PY - 2015 DA - 2015// TI - Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage JO - Nat Biotechnol VL - 33 UR - https://doi.org/10.1038/nbt.3247 DO - 10.1038/nbt.3247 ID - Bar-Nur2015 ER - TY - JOUR AU - Maza, I. AU - Caspi, I. AU - Zviran, A. AU - Chomsky, E. AU - Rais, Y. AU - Viukov, S. PY - 2015 DA - 2015// TI - Transient acquisition of pluripotency during somatic cell transdifferentiation with iPSC reprogramming factors JO - Nat Biotechnol VL - 33 UR - https://doi.org/10.1038/nbt.3270 DO - 10.1038/nbt.3270 ID - Maza2015 ER - TY - STD TI - Lim KT, Lee SC, Gao Y, Kim KP, Song G, An SY, et al. Small molecules facilitate single factor-mediated hepatic reprogramming. Cell Rep. 2016;15:814–829. ID - ref36 ER - TY - JOUR AU - Clayton, D. F. AU - Darnell, J. E. PY - 1983 DA - 1983// TI - Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes JO - Mol Cell Biol VL - 3 UR - https://doi.org/10.1128/MCB.3.9.1552 DO - 10.1128/MCB.3.9.1552 ID - Clayton1983 ER - TY - JOUR AU - Schwanhausser, B. AU - Busse, D. AU - Li, N. AU - Dittmar, G. AU - Schuchhardt, J. AU - Wolf, J. PY - 2011 DA - 2011// TI - Global quantification of mammalian gene expression control JO - Nature VL - 473 UR - https://doi.org/10.1038/nature10098 DO - 10.1038/nature10098 ID - Schwanhausser2011 ER - TY - JOUR AU - Krause, P. AU - Rave-Frank, M. AU - Wolff, H. A. AU - Becker, H. AU - Christiansen, H. AU - Koenig, S. PY - 2010 DA - 2010// TI - Liver sinusoidal endothelial and biliary cell repopulation following irradiation and partial hepatectomy JO - World J Gastroenterol VL - 16 UR - https://doi.org/10.3748/wjg.v16.i31.3928 DO - 10.3748/wjg.v16.i31.3928 ID - Krause2010 ER - TY - JOUR AU - Petersen, B. E. AU - Bowen, W. C. AU - Patrene, K. D. AU - Mars, W. M. AU - Sullivan, A. K. AU - Murase, N. PY - 1999 DA - 1999// TI - Bone marrow as a potential source of hepatic oval cells JO - Science VL - 284 UR - https://doi.org/10.1126/science.284.5417.1168 DO - 10.1126/science.284.5417.1168 ID - Petersen1999 ER - TY - JOUR AU - Marfil, V. AU - Blazquez, M. AU - Serrano, F. AU - Castell, J. V. AU - Bort, R. PY - 2015 DA - 2015// TI - Growth-promoting and tumourigenic activity of c-Myc is suppressed by Hhex JO - Oncogene VL - 34 UR - https://doi.org/10.1038/onc.2014.240 DO - 10.1038/onc.2014.240 ID - Marfil2015 ER -