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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model

Fig. 4

a Experimental design for the in vivo study. Black arrows indicate MRI monitoring, at which time blood samples were obtained for analytical determinations. b T1 vs T2 cardiac function studies. Analysis of cardiac function parameters (left ventricular ejection fraction (LVEF), cardiac output (CO), stroke volume (SV) and heart rate (HR)), comparing T1 and T2 for each group (*p ≤0.05). c Cell localization by MRI. T2-star CMR representative images in a long-axis view of a heart that received paMSC-GFP + SPIO cells vs the control group, at different time points. T1, baseline before cell transplant; T2, 0–48-h follow-up; T3, 15 days; T4, 30 days. White arrows indicate SPIO-labeled cells. AMI acute myocardial infarction, GFP green fluorescent protein, HGF hepatocyte growth factor, IGF-1 insulin-like growth factor-1, paMSC pig mesenchymal stem cells from adipose tissue

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