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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Transcriptional profiling reveals intrinsic mRNA alterations in multipotent mesenchymal stromal cells isolated from bone marrow of newly-diagnosed type 1 diabetes patients

Fig. 5

CXCL12, CCL2, and other migration-related molecules are differentially regulated in T1D-MSCs. Absolute gene expression of genes encoding a chemokines and b chemokine receptors. Genes with multiple probes were represented by the median value. The absolute gene expression value (EV) was log2-transformed, and blue indicates high expression. c Heatmap of the migration-related genes differentially expressed between MSCs from healthy donors (Control, n = 4) and T1D patients (Diabetic, n = 4) (FC > 2, p < 0.05, Student t test, Benjamini Hochberg correction). Upregulated genes are shown in red and downregulated genes in green. d Relative expression of CXCL12 by real-time PCR (Diabetic, n = 7; Control, n = 10). Mann-Whitney U test, p = 0.0054

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