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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Transcriptional profiling reveals intrinsic mRNA alterations in multipotent mesenchymal stromal cells isolated from bone marrow of newly-diagnosed type 1 diabetes patients

Fig. 8

Pathway analysis suggesting hyperactivation of sympathetic nervous system signaling in T1D-MSCs. GSEA analysis of differentially expressed probes between T1D-MSCs and C-MSCs. a Enrichment analysis in KEGG pathways positively correlated with T1D-MSCs relative to C-MSCs; blue indicates KEGG pathways with higher normalized enrichment score (NES). Only data sets with p < 0.05 and FDR > 0.25 are shown. b Enrichment plot of the neuroactive ligand–receptor interaction KEGG pathway: green curve indicates the enrichment score (ES); black vertical dashed lines specify the maximum enrichment score. c Heatmap showing expression of genes in the leading edge subsets. The ADRB3 gene is shown in bold. Diabetic T1D-MSCs, Control C-MSCs

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Stem Cell Research & Therapy

ISSN: 1757-6512