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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Bmi1 + cardiac progenitor cells contribute to myocardial repair following acute injury

Fig. 1

Bmi1-CPC have a stemness profile and upstream regulators related to cardiac development and pluripotency. a Heat map of matched samples (n = 4 replicates; 6 mice/replicate) in high-throughput RNAseq analysis of Bmi1-CPC and Sca-1-YFP cells. b RNAseq gene summary. c Gene Ontology (GO) heat map including significant terms analysis (adjusted P < 0.05) of genes differentially expressed in Bmi1-CPC versus Sca-1-YFP compartments. GO analysis of significantly over- and under-represented terms with FatiGO. d Pluripotency pathway analysis. Comparative expression of stemness-related genes. Red indicates significant overexpression in Bmi1-CPC and green significant overexpression in Sca-1-YFP populations. Numbers in red represent logarithmic fold change (log FC). e IPA analysis of the Notch pathway in Bmi1-CPC versus Sca-1-YFP populations. Red indicates significant overexpression in Bmi1-CPC and green significant overexpression in Sca-1-YFP populations. Numbers in red represent log FC. f IPA prediction for main upstream regulators in the Bmi1-CPC population. g IPA prediction for main upstream regulators in the Sca-1-YFP population

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