Fig. 2

Activation of Bmi1-CPC after acute myocardial infarction. a Timeline for analysis of Bmi1-CPC cells and progeny. b Number of YFP⁺ cells obtained by FACS sorting 5 days post-acute myocardial infarction (AMI; n = 9) compared to the uninjured heart (homeostatic) condition (n = 15). **P < 0.01. Data shown as mean ± SEM. c Cell cycle study of freshly isolated YFP⁺ cells after EdU administration to Bmi1-YFP mice in physiological (homeostasis; top) and post-AMI conditions (bottom) (n = 4). *P < 0.05, **P < 0.01. d Partial transverse section of an injured Bmi1-YFP left ventricle 15 days post-AMI (left) and detailed YFP⁺ clusters located in the infarcted area (right). Scale bars = 200 μm (left), 50 μm (right panels)