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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Bmi1 + cardiac progenitor cells contribute to myocardial repair following acute injury

Fig. 3

Bmi1-CPC upregulate pathways related to proliferation and cell motility and downregulate some pluripotent genes after cardiac injury. a Heat map of matched samples (nā€‰=ā€‰4 replicates, 2ā€“3 mice/replicate) in the high-throughput RNAseq analysis of sorted Bmi1-CPC (YFP+) cells from adult TM-induced control mice (non-infarcted) and mice subjected to acute myocardial infarction (AMI) at 5 days post-treatment. b Heat map of molecular and cellular functions in Bmi1-CPC 5 days post-AMI, compared to counterparts from non-infarcted hearts, and classified by activation z-score. c Differential expression of genes implicated in pluripotency and muscle contractility and calcium management. Genes are classified as down- (red) and upregulated (blue) in sorted Bmi1-CPC 5 days post-AMI by comparison with Bmi1-CPC counterparts from non-infarcted hearts. d Heat map of proliferation and cell migration functions and genes related to the extracellular compartment, immunomodulation, cytokines, chemokines, and growth factors in sorted Bmi1-CPC 5 days post-AMI by comparison with Bmi1-CPC counterparts from non-infarcted hearts. Color scale intensity is related to gene log fold change (FC)

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