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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Adipose tissue-derived stem cells suppress hypertrophic scar fibrosis via the p38/MAPK signaling pathway

Fig. 7

ADSC-CM decreased scar formation through the p38/MAPK signaling pathway in mouse excisional models. a, b The wound healing process in BALB/c mice injected intradermally with DMEM or an 80 % concentration of ADSC-CM in the presence of p38 inhibitor and/or activator at different time points. Relative distances (pixels) were analyzed by Image Pro Plus software and are shown as a histogram. c, d H&E staining showed less inflammatory cellular infiltration and collagen production in the p38 inhibitor group; anisomycin reversed the function and led to more inflammatory cellular infiltration and collagen synthesis. The histologic scores are shown by a histogram. Scale bars = 400 μm. e P38 inhibitor groups showed more ordered and thinner collagen fibers by Masson's trichrome staining; on the contrary, anisomycin represented more disordered and denser collagen fibers. Scale bars = 50 μm. *P < 0.05. A anisomycin, CM conditioned medium, D days, DMEM (D) Dulbecco’s modified Eagle medium, S SB203580

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