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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Direct conversion of mouse embryonic fibroblasts into functional keratinocytes through transient expression of pluripotency-related genes

Fig. 1

Conversion of mouse embryonic fibroblasts (MEFs) to functional keratinocytes (KCs), without isolating an induced pluripotent stem cell (iPSC) intermediate. a The hypothesis behind the experimental design. b After a brief initiation of pluripotency-inducing transcriptional reprogramming by transduction with Sox2, Oct4, and Klf4, induced MEFs are subsequently pushed towards the epidermal lineage by retinoic acid (RA) and bone morphogenetic protein-4 (BMP-4) treatment. DKSF defined keratinocyte serum free, IKC induced keratinocyte

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Stem Cell Research & Therapy

ISSN: 1757-6512