Fig. 4From: Therapeutic effects of human gingiva-derived mesenchymal stromal cells on murine contact hypersensitivity via prostaglandin E2–EP3 signalingTherapeutic effects of various MSC administration methods. a Intravenous injection 1 h after challenge resulted in no significant reduction of ear thickness, but intravenous injection 1 day before sensitization and 1 day before challenge resulted in significant reduction of ear thickness compared with CHS mice. n = 10 independent animals/group. b Local injection 1 day before sensitization, 1 day before challenge, and 1 h after challenge consistently led to significant reduction of ear thickness. n = 10 independent animals/group. c ELISA of TNF-α production showed that local GMSC injection 1 day before challenge and 1 h after challenge significantly reduced TNF-α levels compared with intravenous injection. n = 5 independent animals/group. *p < 0.05; **p < 0.01; ns nonsignificance. CHS contact hypersensitivityBack to article page