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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Therapeutic interactions between mesenchymal stem cells for healing medication-related osteonecrosis of the jaw

Fig. 3

Accumulation of GFP-transgenic injected MSCs into diseased mice. a Experimental protocol for the in-vivo experiments. Wild-type C57BL/6 N mice received both Dex and Zol administered intravenously. MSCs from GFP-transgenic mice were injected into the mice 1 day after tooth extraction. b In various organs and around the extraction site, injected MSCs (CD-90/GFP-FITC double-positive cells) selectively accumulated into the connective tissue close to the blood vessels. However, no double-positive MSCs were observed in the kidney and gingival mucosa. Scale bar, 100 μm. n = 5 × 2 groups. c-MSC control mesenchymal stem cell, d days, d-MSC diseased mesenchymal stem cell, GFP green fluorescent protein, i.p. intraperitoneal, i.v. intravenous. The right panel showed graphially the number of GFP and CD90 positive cells in each organs. Bars represent the mean ± SD of six independent experiments. *P<0.05

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