Fig. 3

Hypoxia improves the reprogramming of ETV2 of fibroblasts into EPCs. HFs were negative for both CD31 and VEGFR2 (a), while ETV2 transduced cells contained a small population of CD31⁺VEGFR2^+/− (b). In the hypoxia condition, ETV2 transduced fibroblasts significantly increased to form CD31⁺VEGFR2⁺ cells (c). To evaluate some cell characteristics from two cell populations, all CD31⁺ cells in the groups of normoxia and transduction with ETV2 (d) and of hypoxia and transduction with ETV2 (e) were sorted