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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: The ACVR1 R206H mutation found in fibrodysplasia ossificans progressiva increases human induced pluripotent stem cell-derived endothelial cell formation and collagen production through BMP-mediated SMAD1/5/8 signaling

Fig. 2

Loss of endothelial lineage commitment of fibrodysplasia ossificans progressiva (FOP) human induced pluripotent stem cell-derived endothelial cells (iECs). a Gene expression analysis of endothelial markers by quantitative PCR of wild type (WT) and FOP iECs. b Mesenchymal/fibroblastic (FSP-1, CD34), mature chondrogenic (COL2A1), and osteogenic (COL1A1, ALPL) gene expression were statistically different by Student’s t test: * p < 0.05, ** p < 0.01. Error bars represent the mean ± one standard deviation of at least three independent replicates for each of the three WT and four FOP iEC lines

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Stem Cell Research & Therapy

ISSN: 1757-6512