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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exendin-4 enhances the differentiation of Wharton’s jelly mesenchymal stem cells into insulin-producing cells through activation of various β-cell markers

Fig. 4

Gene expression analyses by qRT-PCR for cells induced by individual extrinsic factors, namely exendin-4 alone (Ex), exendin-4 plus nicotinamide (Ex + NA), and exendin-4 plus nicotinamide and β-mercaptoethanol (Ex + NA + BME), in 5 % FBS HG-DMEM. Gene expression analyses were done for several β-cell-related genes, namely a Pdx-1, b Nkx2.2, c Isl-1 and d MafA presented as relative mRNA expression levels in induced cells relative to their uninduced control counterparts. Results presented as mean ± standard error of mean for three independent experiments. *Means are significantly different from control at p < 0.05. #Means are significantly different from exendin-4 alone (Ex) at p < 0.05

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