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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Human umbilical cord-derived mesenchymal stem cells protect against experimental colitis via CD5+ B regulatory cells

Fig. 4

hUC-MSCs alter T helper cell subgroups in colitis mice. Populations of Th1/Th2/Th17 cells as a proportion of total CD4+ cells were evaluated by flow cytometry. Cells were co-stained with antibodies against CD3, CD8, interferon (IFN)-γ, interleukin (IL)-4, or IL-17 (CD4+ cells). CD3+CD8- cells were gated (a). CD4+IFN-γ+, CD4+IL-4+, and CD4+IL-17+ cells were defined as Th1, Th2, and Th17 cells, respectively. Representative dot plots are shown in panels b–c. Proportions of Th1 and Th17 cells in the four participant groups are shown in panels d–g. Data are presented as plots with P value. n = 9 for each group; * P < 0.05 vs. MSC-treated mice. hUC-MSC human umbilical cord-derived mesenchymal stem cell, TNBS trinitrobenzenesulfonic acid

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