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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: C-reactive protein can upregulate VEGF expression to promote ADSC-induced angiogenesis by activating HIF-1α via CD64/PI3k/Akt and MAPK/ERK signaling pathways

Fig. 8

Schematic representation of the molecular mechanism for CRP regulation of VEGF in ADSCs. CRP binds to the membrane surface antigen FCγRI (CD64) on ADSCs and then induces ERK1/2 and Akt phosphorylation, which activates HIF-1α to enter the nucleus and bind to hypoxia-response element sites in the VEGF promoter, stimulating VEGF gene and protein expression. CRP C-reactive protein, VEGF vascular endothelial growth factor, HIF-1α, hypoxia inducible factor-1α, HRE hypoxia-response element

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