Table 1 Top canonical pathways from the IPA knowledge base that involve proteins differentially expressed in young compared with old chondrogenic, tenogenic and osteogenic constructs

Chondrogenic^a

LXR/RXR activation

6.01 × 10^–7

8/121 (0.066)

FXR/RXR activation

8.69 × 10^–7

8/127 (0.062)

Acute phase response signalling

7.36 × 10^–6

8/169 (0.047)

Cholesterol biosynthesis I

5.49 × 10^–5

3/13 (0.231)

Cholesterol biosynthesis II

5.49 × 10^–5

3/13 (0.231)

Tenogenic^a

Glycolysis I

5.15 × 10^–9

7/25 (0.28)

Gluconeogenesis I

1.85 × 10^–7

6/25 (0.24)

ILK signalling

6.45 × 10^–7

12/186 (0.065)

Mitochondrial dysfunction

1.96 × 10^–6

11/171 (0.064)

Protein ubiquitination pathway

3.10 × 10^–6

13/255 (0.051)

Osteogenic^b

Mitochondrial dysfunction

1.29 × 10^–4

5/171 (0.029)

Lipid antigen presentation by CD1

2.51 × 10^–3

2/26 (0.077)

Integrin signalling

2.68 × 10^–3

4/202 (0.02)

Oxidative phosphorylation

3.79 × 10^–3

3/109 (0.028)

Glycerol-3-phosphate shuttle

8.58 × 10^–3

1/3 (0.333)