Table 2 Top scoring networks from the IPA knowledge base that involve proteins differentially expressed in young compared with old chondrogenic, tenogenic and osteogenic constructs

Chondrogenic^a

Cell death and survival, lipid metabolism, small molecule biochemistry

43

Cellular movement, cell death and survival, cancer

33

Connective tissue disorders, haematological disease, hereditary disorder

31

Cellular assembly and organisation, cellular development, connective tissue development and function

28

Cell signalling, nucleic acid metabolism, small molecule biochemistry

26

Tenogenic^a

Carbohydrate metabolism, haematological disease, immunological disease

59

Developmental disorder, hereditary disorder, inflammatory disease

43

Cell-to-cell signalling and interaction, embryonic development, tissue development

36

Endocrine system development and function, energy production, small molecule biochemistry

36

Cellular assembly and organisation, cellular function and maintenance, cellular compromise

31

Osteogenic^b

Cellular assembly and organisation, tissue development, infectious disease

58

Cellular compromise, developmental disorder, haematological disease

32

Protein synthesis, developmental disorder, hereditary disorder

29

Lipid metabolism, nucleic acid metabolism, small molecule biochemistry

8