A proteomic analysis of chondrogenic, osteogenic and tenogenic constructs from ageing mesenchymal stem cells

Table 4 Summary of significant functional categories, canonical pathways and networks identified from DE proteins by IPA in constructs made from young or old MSCs for chondrogenic, tenogenic and osteogenic constructs

Biological processes	Chondrogenic^a	Tenogenic^a	Osteogenic^b
Antioxidant changes	✓	✓	✓
Cell death and survival	✓	✓	✓
Cytoskeleton changes	✓	✓	✓
Energy metabolism	x	✓	✓
Protein metabolism	x	✓	✓
Lipid metabolism	✓	x	✓
Musculoskeletal abnormalities increased	✓	✓	x
Cell movement	✓	✓	✓
Cell proliferation	✓	✓	✓
Integrin signalling	x	✓	✓

^aSignificant DE proteins with p < 0.05, q < 0.05 and ±2-fold change
^bSignificant DE proteins with p < 0.05 and ±2-fold change
DE differentially expressed, IPA ingenuity pathway analysis, MSC mesenchymal stem cell

ISSN: 1757-6512