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Fig. 10 | Stem Cell Research & Therapy

Fig. 10

From: Comparative study of allogenic and xenogeneic mesenchymal stem cells on cisplatin-induced acute kidney injury in Sprague-Dawley rats

Fig. 10

Renal pathological changes of experimental groups at different time points. Pathological changes in cisplatin-injected rats sacrificed at day 4 (a) showed marked degenerative changes and atrophic tubules in OSOM (H&E, ×200). Pathological changes in cisplatin-injected and rat bone marrow stem cells (rBMSCs)-treated rats (b), human adipose tissue-derived stem cells (hADSCs)-treated rats (c), and human amniotic fluid-derived stem cells (hAFSCs)-treated rats (d) sacrificed at day 4 showed regenerative changes in the OSOM in the form of many regenerating tubules lined by large cells with large hyperchromatic nuclei with few solid sheets (H&E, B and D × 200, C × 40). Pathological changes in cisplatin-injected rats sacrificed at day 7 (e) showed combined degenerative and regenerative changes (H&E, ×200). Pathological changes in cisplatin-injected and rBMSCs-treated rats (f), hADSCs-treated rats (g), and hAFSCs-treated rats (h) sacrificed at day 7 showed less marked degenerative changes and many regenerative changes in the OSOM in the form of many interstitial solid sheets (H&E, F and H × 200, G × 100). Pathological changes in cisplatin-injected rats sacrificed at day 11 (i) showed more marked degenerative changes and mild interstitial round cell infiltrate (H&E, ×200). Pathological changes in cisplatin-injected and rBMSCs-treated rats (j), hADSCs-treated rats (k), and hAFSCs-treated rats (l) sacrificed at day 11 showed more regenerative changes, few necrotic tubules, and interstitial round cell infiltrates (H&E, J × 100, and K and L × 200). Pathological changes in cisplatin-injected rats sacrificed at day 30 (m) showed mild peritubular and perivascular fibrosis (H&E, ×100). Pathological changes in cisplatin-injected and rBMSCs-treated rats (n), hADSCs-treated rats (o), and hAFSCs-treated rats (p) sacrificed at day 30 showed less chronic changes as regard the tubular atrophy and the renal fibrosis (H&E, N and O × 100, P × 40)

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