TY - JOUR AU - Saad, Ahmed AU - Zhu, Xiang-Yang AU - Herrmann, Sandra AU - Hickson, LaTonya AU - Tang, Hui AU - Dietz, Allan B. AU - van Wijnen, Andre J. AU - Lerman, Lilach AU - Textor, Stephen PY - 2016 DA - 2016/09/09 TI - Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia JO - Stem Cell Research & Therapy SP - 128 VL - 7 IS - 1 AB - Adipose-derived MSC (AMSCs) possess angiogenic and immunomodulatory properties that may modulate kidney regeneration. Whether these properties are retained in older patients with atherosclerotic vascular disease is poorly understood. Hypoxic conditions are known to modify properties and growth characteristics of AMSCs. We tested the hypothesis that AMSCs from older patients with atherosclerotic renovascular disease (RVD) differ from normal kidney donors, and whether hypoxia changes their functional and molecular properties to promote angiogenesis. SN - 1757-6512 UR - https://doi.org/10.1186/s13287-016-0389-x DO - 10.1186/s13287-016-0389-x ID - Saad2016 ER -