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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway

Fig. 4

Internalization of hiPS-MSC-Exos in human BMSCs, exosome release from β-TCP, and their pro-osteogenesis effects on the recipient cells. A (a) DiO-labeled exosome release from β-TCP over 48 h. (b) Accumulated release of exosomes from β-TCP over 5 days. B Exosomes (Exos) enhanced the proliferation of hBMSCs as analyzed by Cell Counting Kit-8 assay. C Exosomes stimulated the migration of BMSCs as analyzed by migration assay. Scale bars = 250 μm. D Quantitative analysis of (C). E, F Incubation of hBMSCs with exosomes resulted in a dose-dependent increase in the alkaline phosphatase (ALP) staining and activity. Dunnett t test; *p < 0.05 compared with the control group, # p < 0.05 compared with the Exos 5 × 1011 particles/mL group

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