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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway

Fig. 5

Differential expression of mRNAs between exosome-treated and control groups. a The differentially expressed (DE) genes in hBMSCs in response to exosome (Exos) stimulation are illustrated as a heat map. A p value cut-off of 0.05 and a fold-value change of ≥2 were used as a filter to identify the DE genes. b Enrichment analysis of all DE genes was performed. The top ten enriched pathways associated with exosome stimulation are shown. c A heat map of PI3K/Akt signaling pathway-related DE genes was generated. d The altered expression of PI3K/Akt signaling-related genes was confirmed by qRT-PCR analysis. ANOVA; *p < 0.05 compared with the control group

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Stem Cell Research & Therapy

ISSN: 1757-6512