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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Exosomes/tricalcium phosphate combination scaffolds can enhance bone regeneration by activating the PI3K/Akt signaling pathway

Fig. 6

Involvement of PI3K/Akt signaling in the exosome-induced osteogenic responses from BMSCs. a Exosomes (Exos) induced the activation of the PI3K/Akt signaling pathway and increased the protein levels of osteogenesis-related molecules; these effects by exosomes were abolished by the PI3K inhibitor (LY294002; 10 μM). b The exosome-treated hBMSCs showed much higher levels of alkaline phosphatase (ALP) and Alizarin red S (ARS) staining compared with the control groups on days 10 and 14, respectively; these effects were inhibited by LY294002

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Stem Cell Research & Therapy

ISSN: 1757-6512