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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Improved osteogenesis and upregulated immunogenicity in human placenta-derived mesenchymal stem cells primed with osteogenic induction medium

Fig. 5

Subpopulations of PBMCs and spleen cells in BALB/c mice immunized by MSCs and De-MSCs. BALB/c mice were injected with MMC-treated MSCs, Ob-MSCs, De-MSCs or Re-MSCs subcutaneously. PBMCs (5 d after injection) and splenocytes (7 d after injection) were collected and analyzed by FCM. CD4+CD25+ cells, CD80+CD11b+ cells, CD80+CD11c+ cells, and CD80+CD45R+ cells were gated as activated T cells, activated monocytes, activated dendritic cells and activated B cells respectively. (a–b) Subpopulations of PBMCs. (c–d) Subpopulations of splenocytes. Values of gated cells presented in the histogram were mean ± SD of three independent experiments. De-MSCs dedifferentiated mesenchymal stem cells, MSCs mesenchymal stem cells, Ob-MSCs MSC-derived osteoblasts, Re-MSCs osteoblasts derived from De-MSCs

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Stem Cell Research & Therapy

ISSN: 1757-6512