Fig. 5

Pretreatment of MSCs with poly(I:C) and LPS generated a differential modulation of Th1 and Th17 cells in EAE mice. Lymph nodes were removed from different groups of treatments at day 27. (a) Th1 detection using CD4⁺IFN-γ for the five groups of mice. (b) Th17 detection (CD4⁺IL-17⁺) for the five groups of mice. Bars represent the mean ± SEM, significant differences calculated using t tests (*p < 0.05, **p < 0.001). MSCsPoly MSCs pretreated with poly(I:C) for 1 hour, MSCsLPS MSCs pretreated with LPS for 1 hour