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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Specific disruption of Lnk in murine endothelial progenitor cells promotes dermal wound healing via enhanced vasculogenesis, activation of myofibroblasts, and suppression of inflammatory cell recruitment

Fig. 6

Effects of a Lnk-deficient EPC transplant on wound repair in mice with STZ-induced diabetes. a To establish a mouse model of type 1 diabetes mellitus (T1DM), blood glucose was assessed after a streptozotocin (STZ) injection. b H&E staining of a tissue slice shows necrosis of β-cells in the pancreas (magnification × 40). c After injection of EPCs into an excisional wound of normal mice or mice with STZ-induced diabetes, photographs of the wound were captured on days 0–10. d The graph shows the proportion of the wound area at the indicated time points post wounding. Values are mean ± SEM; * p < 0.05 and ** p < 0.01 compared to injection with PBS in mice with STZ-induced diabetes, # p < 0.05 and ## p < 0.01 compared to injection of WT EPCs into mice with STZ-induced diabetes

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Stem Cell Research & Therapy

ISSN: 1757-6512